Development and Immunoprotection of Bacterium-like Particle Vaccine against Infectious Bronchitis in Chickens
نویسندگان
چکیده
Infectious bronchitis (IB) is a major threat to the global poultry industry. Despite availability of commercial vaccines, IB epidemic has not been effectively controlled. The exploration novel IBV vaccines may provide new way prevent and control IB. In this study, BLP-S1, bacterium-like particle displaying S1 subunit infectious virus (IBV), was constructed using GEM-PA surface display system. immunoprotective efficacy results showed that BLP-S1 can induce specific IgG sIgA immune responses, providing protection rate 90% against infection in 14-day-old chickens. These suggest potential for development with good immunogenicity immunoprotection.
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ژورنال
عنوان ژورنال: Vaccines
سال: 2023
ISSN: ['2076-393X']
DOI: https://doi.org/10.3390/vaccines11081292